BDBM50173839 6-(benzyl(methyl)amino)-4-(3-chloro-4-fluorophenylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL198647

SMILES: CN(Cc1ccccc1)c1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cn1)C#N

InChI Key: InChIKey=WYRYPKHMUJUPOV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173839   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173839 (6-(benzyl(methyl)amino)-4-(3-chloro-4-fluorophenyl...) Show SMILES CN(Cc1ccccc1)c1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cn1)C#N Show InChI InChI=1S/C23H17ClFN5/c1-30(14-15-5-3-2-4-6-15)22-10-18-21(13-28-22)27-12-16(11-26)23(18)29-17-7-8-20(25)19(24)9-17/h2-10,12-13H,14H2,1H3,(H,27,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair