BDBM50173842 6-(2-morpholinoethylamino)-4-(4-(trifluoromethyl)phenylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL198577

SMILES: FC(F)(F)c1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1

InChI Key: InChIKey=ICAYNNRAEBXXLL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173842   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173842 (6-(2-morpholinoethylamino)-4-(4-(trifluoromethyl)p...) Show SMILES FC(F)(F)c1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1 Show InChI InChI=1S/C22H21F3N6O/c23-22(24,25)16-1-3-17(4-2-16)30-21-15(12-26)13-28-19-14-29-20(11-18(19)21)27-5-6-31-7-9-32-10-8-31/h1-4,11,13-14H,5-10H2,(H,27,29)(H,28,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair