BDBM50173845 4-(3-chloro-4-fluorophenylamino)-6-(3-morpholinopropylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL198581

SMILES: Fc1ccc(Nc2c(cnc3cnc(NCCCN4CCOCC4)cc23)C#N)cc1Cl

InChI Key: InChIKey=NXVAWZCBOMXMGU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173845   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173845 (4-(3-chloro-4-fluorophenylamino)-6-(3-morpholinopr...) Show SMILES Fc1ccc(Nc2c(cnc3cnc(NCCCN4CCOCC4)cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClFN6O/c23-18-10-16(2-3-19(18)24)29-22-15(12-25)13-27-20-14-28-21(11-17(20)22)26-4-1-5-30-6-8-31-9-7-30/h2-3,10-11,13-14H,1,4-9H2,(H,26,28)(H,27,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair