BDBM50173847 (S)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylpropylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL196771

SMILES: CC[C@H](Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cn1)C#N)c1ccccc1

InChI Key: InChIKey=JJWPJEKOLAXHRB-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173847 ((S)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylpr...) Show SMILES CC[C@H](Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cn1)C#N)c1ccccc1 Show InChI InChI=1S/C24H19ClFN5/c1-2-21(15-6-4-3-5-7-15)31-23-11-18-22(14-29-23)28-13-16(12-27)24(18)30-17-8-9-20(26)19(25)10-17/h3-11,13-14,21H,2H2,1H3,(H,28,30)(H,29,31)/t21-/m0/s1	PDB NCI pathway Reactome pathway KEGG GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair