BDBM50173849 6-(2-morpholinoethylamino)-4-(4-(phenylsulfonyl)phenylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL198739

SMILES: O=S(=O)(c1ccccc1)c1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1

InChI Key: InChIKey=LKGGTYHCRPVGHW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173849   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173849 (6-(2-morpholinoethylamino)-4-(4-(phenylsulfonyl)ph...) Show SMILES O=S(=O)(c1ccccc1)c1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1 Show InChI InChI=1S/C27H26N6O3S/c28-17-20-18-30-25-19-31-26(29-10-11-33-12-14-36-15-13-33)16-24(25)27(20)32-21-6-8-23(9-7-21)37(34,35)22-4-2-1-3-5-22/h1-9,16,18-19H,10-15H2,(H,29,31)(H,30,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair