BDBM50173850 6-(benzylamino)-4-(3-chloro-4-fluorophenylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL200247
SMILES: Fc1ccc(Nc2c(cnc3cnc(NCc4ccccc4)cc23)C#N)cc1Cl
InChI Key: InChIKey=NGQDSIIBTBUSAP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human)) | BDBM50173850 (6-(benzylamino)-4-(3-chloro-4-fluorophenylamino)-1...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Tpl2 kinase by ELISA | Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human)) | BDBM50173850 (6-(benzylamino)-4-(3-chloro-4-fluorophenylamino)-1...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation | Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M | |||||||||||
More data for this Ligand-Target Pair |