BDBM50173852 4-(3-chloro-4-fluorophenylamino)-6-(cyclopentylamino)-1,7-naphthyridine-3-carbonitrile::4-(3-chloro-4-fluorophenylamino)-6-cyclopentylamino-[1,7]naphthyridine-3-carbonitrile::CHEMBL199000

SMILES: Fc1ccc(Nc2c(cnc3cnc(NC4CCCC4)cc23)C#N)cc1Cl

InChI Key: InChIKey=UZSGXMBGJBAMDX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173852   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173852 (4-(3-chloro-4-fluorophenylamino)-6-(cyclopentylami...) Show SMILES Fc1ccc(Nc2c(cnc3cnc(NC4CCCC4)cc23)C#N)cc1Cl Show InChI InChI=1S/C20H17ClFN5/c21-16-7-14(5-6-17(16)22)27-20-12(9-23)10-24-18-11-25-19(8-15(18)20)26-13-3-1-2-4-13/h5-8,10-11,13H,1-4H2,(H,24,27)(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair