Found 3 hits for monomerid = 50174290 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50174290
(4-(5-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)b...)Show SMILES COc1cc(O)ccc1-c1nnc(n1C)C12CCC(CC1)(CC2)c1nc(no1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H26FN5O3/c1-32-22(19-8-7-18(33)15-20(19)34-2)29-30-23(32)25-9-12-26(13-10-25,14-11-25)24-28-21(31-35-24)16-3-5-17(27)6-4-16/h3-8,15,33H,9-14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibitory activity against mouse 11beta-HSD1 |
Bioorg Med Chem Lett 15: 5266-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.052 BindingDB Entry DOI: 10.7270/Q2QC031M |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50174290
(4-(5-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)b...)Show SMILES COc1cc(O)ccc1-c1nnc(n1C)C12CCC(CC1)(CC2)c1nc(no1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H26FN5O3/c1-32-22(19-8-7-18(33)15-20(19)34-2)29-30-23(32)25-9-12-26(13-10-25,14-11-25)24-28-21(31-35-24)16-3-5-17(27)6-4-16/h3-8,15,33H,9-14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of 11beta-HSD1 |
Bioorg Med Chem Lett 18: 2479-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.042 BindingDB Entry DOI: 10.7270/Q2QC04Q0 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50174290
(4-(5-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)b...)Show SMILES COc1cc(O)ccc1-c1nnc(n1C)C12CCC(CC1)(CC2)c1nc(no1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H26FN5O3/c1-32-22(19-8-7-18(33)15-20(19)34-2)29-30-23(32)25-9-12-26(13-10-25,14-11-25)24-28-21(31-35-24)16-3-5-17(27)6-4-16/h3-8,15,33H,9-14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibitory activity against human 11beta-HSD1 |
Bioorg Med Chem Lett 15: 5266-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.052 BindingDB Entry DOI: 10.7270/Q2QC031M |
More data for this Ligand-Target Pair | |