BDBM50174613 4-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-ylmethyl}-amino)-pyridine-2,6-dicarbonitrile::CHEMBL194506
SMILES: C[C@@H]1CCCN1CCc1cc2cc(CNc3cc(nc(c3)C#N)C#N)ccc2o1
InChI Key: InChIKey=UFYKEIQZMJXXNM-MRXNPFEDSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50174613 (4-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine | J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50174613 (4-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine | J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT | |||||||||||
More data for this Ligand-Target Pair |