BDBM50174685 1-(1-chloro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-8-yl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea::CHEMBL372111

SMILES: FC(F)(F)c1cc(NC(=O)Nc2ccc3Oc4ncnc(Cl)c4NCc3c2)ccc1Cl

InChI Key: InChIKey=XWLBLEFIOKFYBR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50174685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50174685 (1-(1-chloro-10,11-dihydro-5-oxa-2,4,11-triaza-dibe...) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc3Oc4ncnc(Cl)c4NCc3c2)ccc1Cl Show InChI InChI=1S/C19H12Cl2F3N5O2/c20-13-3-1-11(6-12(13)19(22,23)24)29-18(30)28-10-2-4-14-9(5-10)7-25-15-16(21)26-8-27-17(15)31-14/h1-6,8,25H,7H2,(H2,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
ImClone Systems Inc Curated by ChEMBL					Assay Description Inhibitory activity against FLT3 kinase in a HTRF assay				Bioorg Med Chem Lett 15: 5474-7 (2005) Article DOI: 10.1016/j.bmcl.2005.08.098 BindingDB Entry DOI: 10.7270/Q2S46RGS
					More data for this Ligand-Target Pair