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BDBM50175143 CHEMBL3809313

SMILES: Cc1cc(C)c(Nc2c(C)cc(C)cc2C)c(C)c1

InChI Key: InChIKey=HSXWOKPAUZMPML-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50175143   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rap guanine nucleotide exchange factor 4


(Homo sapiens (Human))
BDBM50175143
PNG
(CHEMBL3809313)
Show SMILES Cc1cc(C)c(Nc2c(C)cc(C)cc2C)c(C)c1
Show InChI InChI=1S/C18H23N/c1-11-7-13(3)17(14(4)8-11)19-18-15(5)9-12(2)10-16(18)6/h7-10,19H,1-6H3
PDB
MMDB

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PC cid
PC sid
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Similars

PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru...


ACS Med Chem Lett 7: 460-4 (2016)


BindingDB Entry DOI: 10.7270/Q2NC6335
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens (Human))
BDBM50175143
PNG
(CHEMBL3809313)
Show SMILES Cc1cc(C)c(Nc2c(C)cc(C)cc2C)c(C)c1
Show InChI InChI=1S/C18H23N/c1-11-7-13(3)17(14(4)8-11)19-18-15(5)9-12(2)10-16(18)6/h7-10,19H,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 400n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis


ACS Med Chem Lett 7: 460-4 (2016)


BindingDB Entry DOI: 10.7270/Q2NC6335
More data for this
Ligand-Target Pair