BDBM50175155 2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3.2.1]octan-8-yl)ethanamine::2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-yl}-ethylamine::CHEMBL199166
SMILES: NCCN1C2CCC1CC(C2)OC(c1ccc(F)cc1)c1ccc(F)cc1
InChI Key: InChIKey=HKONLYZKJHOXAP-UHFFFAOYSA-N
Data: 10 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL | Assay Description Displacement of [3H]WIN-from DAT in rat brain membrane | Bioorg Med Chem Lett 15: 5419-23 (2005) Article DOI: 10.1016/j.bmcl.2005.08.111 BindingDB Entry DOI: 10.7270/Q2KP82XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Displacement of [3H]WIN35428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting method | J Med Chem 60: 10172-10187 (2017) Article DOI: 10.1021/acs.jmedchem.7b01454 BindingDB Entry DOI: 10.7270/Q2NG4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Displacement of [3H]WIN-35428 from the dopamine transporter in rat caudate putamen | J Med Chem 43: 1085-93 (2000) BindingDB Entry DOI: 10.7270/Q2M61KZ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL | Assay Description Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement. | J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 25.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College Curated by ChEMBL | Assay Description Ability of compound to inhibit dopamine uptake of receptor was determined | Bioorg Med Chem Lett 15: 2149-57 (2005) Article DOI: 10.1016/j.bmcl.2005.02.012 BindingDB Entry DOI: 10.7270/Q2RR20G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL | Assay Description Binding affinity at muscarinic M1 receptor in rat brain by [3H]pirenzepine displacement. | J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Binding affinity at Muscarinic acetylcholine receptor M1 in Rat brain homogenate by [3H]pirenzepine displacement. | J Med Chem 43: 1085-93 (2000) BindingDB Entry DOI: 10.7270/Q2M61KZ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL | Assay Description Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat brain | J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Displacement of [3H]citalopram from Sprague-Dawley rat brain SERT after 60 mins by liquid scintillation counting method | J Med Chem 60: 10172-10187 (2017) Article DOI: 10.1021/acs.jmedchem.7b01454 BindingDB Entry DOI: 10.7270/Q2NG4T2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50175155 (2-(3-(bis(4-fluorophenyl)methoxy)-8-aza-bicyclo[3....) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL | Assay Description Binding affinity at serotonin transporter in rat brain by [3H]-citalopram displacement. | J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4 | |||||||||||
More data for this Ligand-Target Pair |