BindingDB logo
myBDB logout

BDBM50175383 (R)-1-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino)-3-(4-(trifluoromethoxy)phenoxy)propan-2-ol::CHEMBL201065

SMILES: CC(C)(Cc1ccc(F)cc1)NC[C@@H](O)COc1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=FRVZDYYYHDHDGQ-MRXNPFEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175383   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50175383
PNG
((R)-1-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino...)
Show SMILES CC(C)(Cc1ccc(F)cc1)NC[C@@H](O)COc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H23F4NO3/c1-19(2,11-14-3-5-15(21)6-4-14)25-12-16(26)13-27-17-7-9-18(10-8-17)28-20(22,23)24/h3-10,16,25-26H,11-13H2,1-2H3/t16-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR

Bioorg Med Chem Lett 15: 5478-82 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.095
BindingDB Entry DOI: 10.7270/Q2WS8STX
More data for this
Ligand-Target Pair