Found 3 hits for monomerid = 50175750 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175750
(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)Show SMILES CC(C)N1C2CCC1CC(C2)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |THB:11:9:3:5.6,(3.56,-16.01,;2.34,-15.07,;2.54,-13.55,;.92,-15.66,;-.64,-15.7,;-1.83,-14.54,;-1.3,-15.8,;-.06,-16.59,;-.27,-18.33,;-1.84,-18.38,;-.9,-17.52,;-3.17,-19.15,;-3.17,-20.7,;-4.5,-21.48,;-4.5,-23.01,;-5.84,-23.78,;-5.84,-25.32,;-4.5,-26.09,;-4.5,-27.63,;-3.17,-25.31,;-3.17,-23.78,;-1.84,-23,;-5.84,-20.71,;-7.17,-21.48,;-8.51,-20.71,;-8.51,-19.16,;-9.84,-18.39,;-7.17,-18.39,;-7.17,-16.86,;-8.5,-16.1,;-9.83,-16.87,;-8.5,-14.56,;-7.16,-13.78,;-5.83,-14.55,;-5.83,-16.09,;-4.5,-16.87,;-5.84,-19.16,;-4.51,-18.39,)| Show InChI InChI=1S/C31H28Cl3FN2O/c1-17(2)36-21-7-8-22(36)13-18(12-21)19-14-25(23-9-6-20(35)16-28(23)34)24-10-11-30(38)37(29(24)15-19)31-26(32)4-3-5-27(31)33/h3-6,9-11,14-18,21-22H,7-8,12-13H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of P38 alpha MAPK |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065
BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175750
(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)Show SMILES CC(C)N1C2CCC1CC(C2)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |THB:11:9:3:5.6,(3.56,-16.01,;2.34,-15.07,;2.54,-13.55,;.92,-15.66,;-.64,-15.7,;-1.83,-14.54,;-1.3,-15.8,;-.06,-16.59,;-.27,-18.33,;-1.84,-18.38,;-.9,-17.52,;-3.17,-19.15,;-3.17,-20.7,;-4.5,-21.48,;-4.5,-23.01,;-5.84,-23.78,;-5.84,-25.32,;-4.5,-26.09,;-4.5,-27.63,;-3.17,-25.31,;-3.17,-23.78,;-1.84,-23,;-5.84,-20.71,;-7.17,-21.48,;-8.51,-20.71,;-8.51,-19.16,;-9.84,-18.39,;-7.17,-18.39,;-7.17,-16.86,;-8.5,-16.1,;-9.83,-16.87,;-8.5,-14.56,;-7.16,-13.78,;-5.83,-14.55,;-5.83,-16.09,;-4.5,-16.87,;-5.84,-19.16,;-4.51,-18.39,)| Show InChI InChI=1S/C31H28Cl3FN2O/c1-17(2)36-21-7-8-22(36)13-18(12-21)19-14-25(23-9-6-20(35)16-28(23)34)24-10-11-30(38)37(29(24)15-19)31-26(32)4-3-5-27(31)33/h3-6,9-11,14-18,21-22H,7-8,12-13H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of LPS stimulated TNF alpha release in whole blood |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065
BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175750
(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)Show SMILES CC(C)N1C2CCC1CC(C2)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |THB:11:9:3:5.6,(3.56,-16.01,;2.34,-15.07,;2.54,-13.55,;.92,-15.66,;-.64,-15.7,;-1.83,-14.54,;-1.3,-15.8,;-.06,-16.59,;-.27,-18.33,;-1.84,-18.38,;-.9,-17.52,;-3.17,-19.15,;-3.17,-20.7,;-4.5,-21.48,;-4.5,-23.01,;-5.84,-23.78,;-5.84,-25.32,;-4.5,-26.09,;-4.5,-27.63,;-3.17,-25.31,;-3.17,-23.78,;-1.84,-23,;-5.84,-20.71,;-7.17,-21.48,;-8.51,-20.71,;-8.51,-19.16,;-9.84,-18.39,;-7.17,-18.39,;-7.17,-16.86,;-8.5,-16.1,;-9.83,-16.87,;-8.5,-14.56,;-7.16,-13.78,;-5.83,-14.55,;-5.83,-16.09,;-4.5,-16.87,;-5.84,-19.16,;-4.51,-18.39,)| Show InChI InChI=1S/C31H28Cl3FN2O/c1-17(2)36-21-7-8-22(36)13-18(12-21)19-14-25(23-9-6-20(35)16-28(23)34)24-10-11-30(38)37(29(24)15-19)31-26(32)4-3-5-27(31)33/h3-6,9-11,14-18,21-22H,7-8,12-13H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.990 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of TNF alpha release in THP1 cells |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065
BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this
Ligand-Target Pair | |
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