BDBM50175765 1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-(3-hydroxypropoxy)phenyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)urea hydrochloride::CHEMBL454397::CHEMBL539597::CHEMBL573970
SMILES: CCCCn1c2ncccc2c(-c2cccc(OCCCO)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O
InChI Key: InChIKey=HNRUUMLUBDTZHX-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50175765 (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase, Soat (Rattus norvegicus) | BDBM50175765 (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Sumitomo Pharmaceuticals Co., Ltd Curated by ChEMBL | Assay Description Inhibitory activity against ACAT in rat macrophages | Bioorg Med Chem Lett 16: 44-8 (2005) Article DOI: 10.1016/j.bmcl.2005.09.056 BindingDB Entry DOI: 10.7270/Q2PG1SH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase, Soat (Rattus norvegicus) | BDBM50175765 (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of rat macrophages ACAT | J Med Chem 53: 3284-95 (2010) Article DOI: 10.1021/jm901909p BindingDB Entry DOI: 10.7270/Q2639PWV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase, Soat (Rattus norvegicus) | BDBM50175765 (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester... | Bioorg Med Chem 17: 4636-46 (2009) Article DOI: 10.1016/j.bmc.2009.04.059 BindingDB Entry DOI: 10.7270/Q24M94KR | |||||||||||
More data for this Ligand-Target Pair |