Found 27 hits for monomerid = 50176259 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| DrugBank PubMed
| >1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Displacement of [3H]DPDPE from human DOR expressed in CHO cell membranes after 60 mins |
ACS Med Chem Lett 7: 391-6 (2016)
BindingDB Entry DOI: 10.7270/Q2R78H4W |
More data for this Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| >1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes after 60 mins |
ACS Med Chem Lett 7: 391-6 (2016)
BindingDB Entry DOI: 10.7270/Q2R78H4W |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rensselaer Polytechnic Institute
Curated by ChEMBL
| Assay Description Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells |
Bioorg Med Chem Lett 19: 203-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.134 BindingDB Entry DOI: 10.7270/Q2RX9D1K |
More data for this Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rensselaer Polytechnic Institute
Curated by ChEMBL
| Assay Description Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 19: 203-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.134 BindingDB Entry DOI: 10.7270/Q2RX9D1K |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rensselaer Polytechnic Institute
Curated by ChEMBL
| Assay Description Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 19: 203-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.134 BindingDB Entry DOI: 10.7270/Q2RX9D1K |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Opioid receptor mu 1 agonist activity with monoamine (NE, 5-HT) uptake-blocking activity in the 0.8-1 uM range |
J Med Chem 42: 1481-500 (1999)
Article DOI: 10.1021/jm9805034 BindingDB Entry DOI: 10.7270/Q2HX1DCV |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
Reactome pathway KEGG
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| Article PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw Medical University
Curated by ChEMBL
| Assay Description Displacement of [3H]-dihydromorphine from mu opioid receptor in rat cerebral cortex by liquid scintillation counting |
Eur J Med Chem 46: 4992-9 (2011)
Article DOI: 10.1016/j.ejmech.2011.08.006 BindingDB Entry DOI: 10.7270/Q27S7P5W |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Binding affinity towards aldosterone receptor (Mineralocorticoid receptor) |
ACS Med Chem Lett 7: 391-6 (2016)
BindingDB Entry DOI: 10.7270/Q2R78H4W |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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Similars
| DrugBank Article PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of mu opioid receptor |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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Similars
| DrugBank Article PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of 5HT |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| DrugBank Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of Norepinephrine |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of 5HT |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Similars
| DrugBank Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of Norepinephrine |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Binding affinity to mu opioid receptor |
Bioorg Med Chem Lett 18: 1674-80 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.051 BindingDB Entry DOI: 10.7270/Q2VQ33HQ |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of SERT mediated 5-hydroxytryptamine uptake |
Bioorg Med Chem Lett 18: 1674-80 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.051 BindingDB Entry DOI: 10.7270/Q2VQ33HQ |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 3.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of NET mediated norepinephrine uptake |
Bioorg Med Chem Lett 18: 1674-80 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.051 BindingDB Entry DOI: 10.7270/Q2VQ33HQ |
More data for this Ligand-Target Pair | |
Adrenergic Alpha
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy |
J Med Chem 51: 5932-42 (2008)
Article DOI: 10.1021/jm8003152 BindingDB Entry DOI: 10.7270/Q23779MD |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ... |
ACS Med Chem Lett 3: 227-231 (2012)
Article DOI: 10.1021/ml200268w BindingDB Entry DOI: 10.7270/Q2TX3GF4 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 1
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 8.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medicine Greifswald
Curated by ChEMBL
| Assay Description Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis |
J Med Chem 62: 9890-9905 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01301 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of Norepinephrine |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of 5HT |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of Norepinephrine |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of mu opioid receptor |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of mu opioid receptor |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of mu opioid receptor |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay |
ACS Med Chem Lett 7: 391-6 (2016)
BindingDB Entry DOI: 10.7270/Q2R78H4W |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50176259
((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...)Show InChI InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sepracor Inc.
Curated by ChEMBL
| Assay Description Inhibition of reuptake of 5HT |
Bioorg Med Chem Lett 16: 691-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D |
More data for this Ligand-Target Pair | |