BindingDB PrimarySearch

BDBM50176605 (S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)methyl)-4-methoxybenzyl)butanoic acid::CHEMBL202118

SMILES: CC[C@@H](Cc1ccc(OC)c(CNC(=O)c2ccc(c(F)c2)C(F)(F)F)c1)C(O)=O

InChI Key: InChIKey=SSDRFTJAKXCHTF-ZDUSSCGKSA-N

Data: 8 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50176605
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at mouse PPARdelta transfected in HEK293 cells				Bioorg Med Chem Lett 16: 554-8 (2005) Article DOI: 10.1016/j.bmcl.2005.10.049 BindingDB Entry DOI: 10.7270/Q2DF6QS3
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha transfected in HEK293 cells				Bioorg Med Chem Lett 16: 554-8 (2005) Article DOI: 10.1016/j.bmcl.2005.10.049 BindingDB Entry DOI: 10.7270/Q2DF6QS3
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	630	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha containing wild-type I272F domain transfected in HEK293 cells				Bioorg Med Chem Lett 16: 554-8 (2005) Article DOI: 10.1016/j.bmcl.2005.10.049 BindingDB Entry DOI: 10.7270/Q2DF6QS3
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Okayama University Curated by ChEMBL					Assay Description Transactivation of Gal4-fused human PPARdelta expressed in HEK293 cells after 16 to 20 hrs by luciferase reporter gene assay				J Med Chem 54: 331-41 (2011) Article DOI: 10.1021/jm101233f BindingDB Entry DOI: 10.7270/Q2TM7C3T
Okayama University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at PPARgamma transfected in HEK293 cells				Bioorg Med Chem Lett 16: 554-8 (2005) Article DOI: 10.1016/j.bmcl.2005.10.049 BindingDB Entry DOI: 10.7270/Q2DF6QS3
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at PPARdelta transfected in HEK293 cells				Bioorg Med Chem Lett 16: 554-8 (2005) Article DOI: 10.1016/j.bmcl.2005.10.049 BindingDB Entry DOI: 10.7270/Q2DF6QS3
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Okayama University Curated by ChEMBL					Assay Description Transactivation of Gal4-fused human PPARalpha expressed in HEK293 cells after 16 to 20 hrs by luciferase reporter gene assay				J Med Chem 54: 331-41 (2011) Article DOI: 10.1021/jm101233f BindingDB Entry DOI: 10.7270/Q2TM7C3T
Okayama University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM50176605 ((S)-2-(3-((3-fluoro-4-(trifluoromethyl)benzamido)m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at PPARalpha transfected in HEK293 cells				Bioorg Med Chem Lett 16: 554-8 (2005) Article DOI: 10.1016/j.bmcl.2005.10.049 BindingDB Entry DOI: 10.7270/Q2DF6QS3
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair