BDBM50176808 5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benzoimidazole::6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole::CHEMBL389433::US9138393, Liarizole hydrochloride::US9144538, Liarizole hydrochloride::liarozole

SMILES: Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1

InChI Key: InChIKey=UGFHIPBXIWJXNA-UHFFFAOYSA-N

Data: 12 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50176808   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a
Cardiff University					Assay Description The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...				J Enzyme Inhib Med Chem 24: 487-98 (2009) Article DOI: 10.1080/14756360802218334 BindingDB Entry DOI: 10.7270/Q2CR5RZ5
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Procter & Gamble Company US Patent					Assay Description A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...				US Patent US9138393 (2015) BindingDB Entry DOI: 10.7270/Q2GF0S8J
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Procter & Gamble Company US Patent					Assay Description Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...				US Patent US9144538 (2015) BindingDB Entry DOI: 10.7270/Q22806DV
					More data for this Ligand-Target Pair
Cytochrome P450 24A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...				J Med Chem 57: 7702-15 (2014) Article DOI: 10.1021/jm5009314 BindingDB Entry DOI: 10.7270/Q2DN46ND
					More data for this Ligand-Target Pair
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Potency towards cytochrome P 450 26 enzyme activity				Bioorg Med Chem Lett 15: 1669-73 (2005) Article DOI: 10.1016/j.bmcl.2005.01.044 BindingDB Entry DOI: 10.7270/Q2WW7H5R
					More data for this Ligand-Target Pair
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in ATRA-induced human HL60 cell microsomes incubated for 30 mins using ATRA and NADPH by HPLC method				Bioorg Med Chem 23: 1356-65 (2015) Article DOI: 10.1016/j.bmc.2014.11.036 BindingDB Entry DOI: 10.7270/Q2416ZQG
					More data for this Ligand-Target Pair
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in human MCF7 cells				Bioorg Med Chem 16: 8301-13 (2008) Article DOI: 10.1016/j.bmc.2007.06.048 BindingDB Entry DOI: 10.7270/Q2M61M5B
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 (unknown origin) incubated for 45 mins using NADPH by fluorescence assay				Bioorg Med Chem 23: 6763-73 (2015) BindingDB Entry DOI: 10.7270/Q2668G0C
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	4.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin) incubated for 45 mins using NADPH and ATRA by HPLC assay				Bioorg Med Chem 23: 6763-73 (2015) BindingDB Entry DOI: 10.7270/Q2668G0C
					More data for this Ligand-Target Pair
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation counting				J Med Chem 54: 2778-91 (2011) Article DOI: 10.1021/jm101583w BindingDB Entry DOI: 10.7270/Q2TT4R8J
					More data for this Ligand-Target Pair
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation counting				J Med Chem 54: 6803-11 (2011) Article DOI: 10.1021/jm200695m BindingDB Entry DOI: 10.7270/Q2WM1DSJ
					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University Curated by ChEMBL					Assay Description Inhibition of human placental microsome CYP19				Bioorg Med Chem Lett 20: 3050-64 (2010) Article DOI: 10.1016/j.bmcl.2010.03.113 BindingDB Entry DOI: 10.7270/Q2CJ8FFS
					More data for this Ligand-Target Pair
Cytochrome CYP26A1 (Homo sapiens (Human))	BDBM50176808 (5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benz...) Show SMILES Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 Show InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CYP26A1 in ATRA-induced human HL60 cell microsomes incubated for 30 mins in dark condition with NADPH and ATRA by HPLC method				Bioorg Med Chem 23: 6763-73 (2015) BindingDB Entry DOI: 10.7270/Q2668G0C
					More data for this Ligand-Target Pair