Found 13 hits for monomerid = 50177053 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor
(RAT) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranes |
J Med Chem 48: 7374-88 (2005)
Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(Rattus norvegicus (Rat)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 194 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]MPEP from rat cortex mGluR5 |
J Med Chem 48: 7374-88 (2005)
Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 442 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization |
J Med Chem 48: 7374-88 (2005)
Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4 (mGluR4)
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR4 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Labs
Curated by ChEMBL
| Assay Description Antagonist activity at mGlu1 receptor |
J Med Chem 50: 2563-8 (2007)
Article DOI: 10.1021/jm060950g BindingDB Entry DOI: 10.7270/Q2XS5W7Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR2 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 442 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(Rattus norvegicus (Rat)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocampus
Curated by ChEMBL
| Assay Description Inhibition of rat mGluR1 |
Eur J Med Chem 43: 1025-34 (2008)
Article DOI: 10.1016/j.ejmech.2007.06.024 BindingDB Entry DOI: 10.7270/Q2V987VM |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization |
J Med Chem 48: 7374-88 (2005)
Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0 |
More data for this Ligand-Target Pair | |
GRM7
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR7 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053 BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this Ligand-Target Pair | |