BDBM50177241 4-(3-bromo-8-chloro-6,11-dihydro-5-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylicacid 1-(isobutyl-amide) 2-[(pyridin-3-ylmethyl)-amide]::CHEMBL370411

SMILES: CC(C)CNC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12

InChI Key: InChIKey=MDBOTFRSILQXBP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50177241 (4-(3-bromo-8-chloro-6,11-dihydro-5-benzo[5,6]cyclo...) Show SMILES CC(C)CNC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H34BrClN6O2/c1-19(2)14-36-30(40)38-11-10-37(18-26(38)29(39)35-16-20-4-3-9-33-15-20)28-25-8-7-24(32)13-21(25)5-6-22-12-23(31)17-34-27(22)28/h3-4,7-9,12-13,15,17,19,26,28H,5-6,10-11,14,16,18H2,1-2H3,(H,35,39)(H,36,40)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50177241 (4-(3-bromo-8-chloro-6,11-dihydro-5-benzo[5,6]cyclo...) Show SMILES CC(C)CNC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H34BrClN6O2/c1-19(2)14-36-30(40)38-11-10-37(18-26(38)29(39)35-16-20-4-3-9-33-15-20)28-25-8-7-24(32)13-21(25)5-6-22-12-23(31)17-34-27(22)28/h3-4,7-9,12-13,15,17,19,26,28H,5-6,10-11,14,16,18H2,1-2H3,(H,35,39)(H,36,40)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair