BDBM50177255 6-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-6-oxo-hexanoic acid methyl ester::CHEMBL201817
SMILES: COC(=O)CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12
InChI Key: InChIKey=WPZXABAVFMGYIS-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human)) | BDBM50177255 (6-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Princ Curated by ChEMBL | Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay | Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human)) | BDBM50177255 (6-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Princ Curated by ChEMBL | Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells | Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S | |||||||||||
More data for this Ligand-Target Pair |