BDBM50177267 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(6-oxo-heptanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide::CHEMBL408569

SMILES: CC(=O)CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12

InChI Key: InChIKey=ZMPPPCWXZUURIX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177267   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177267 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(=O)CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C32H35BrClN5O3/c1-21(40)5-2-3-7-29(41)39-14-13-38(20-28(39)32(42)37-18-22-6-4-12-35-17-22)31-27-11-10-26(34)16-23(27)8-9-24-15-25(33)19-36-30(24)31/h4,6,10-12,15-17,19,28,31H,2-3,5,7-9,13-14,18,20H2,1H3,(H,37,42)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177267 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(=O)CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C32H35BrClN5O3/c1-21(40)5-2-3-7-29(41)39-14-13-38(20-28(39)32(42)37-18-22-6-4-12-35-17-22)31-27-11-10-26(34)16-23(27)8-9-24-15-25(33)19-36-30(24)31/h4,6,10-12,15-17,19,28,31H,2-3,5,7-9,13-14,18,20H2,1H3,(H,37,42)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair