BDBM50177552 3-(4-((4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)methyl)phenoxy)-N,N-dimethylpropan-1-amine::CHEMBL203910
SMILES: CN(C)CCCOc1ccc(CN2CCC(Cc3cnc[nH]3)CC2)cc1
InChI Key: InChIKey=ZEGYSPXGRXXXRY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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HRH3 (GUINEA PIG) | BDBM50177552 (3-(4-((4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor | Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HRH3 (GUINEA PIG) | BDBM50177552 (3-(4-((4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description Antagonistic activity against histamine H3 receptor in guinea pig ileum | Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50177552 (3-(4-((4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description Inhibition of CYP2D6 by human liver microsome assay | Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X | |||||||||||
More data for this Ligand-Target Pair |