BDBM50177565 CHEMBL380858::N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamino)-1-(2-fluorophenyl)ethyl)piperazin-1-yl)-1-oxopropan-2-yl)-2-(2-methylisoindolin-1-yl)acetamide
SMILES: CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1N(C)Cc2ccccc12)c1ccccc1F
InChI Key: InChIKey=CXNCKVKDTNIURI-XQTVSKJUSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50177565 (CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells | Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50177565 (CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC5R expressed in HEK293 cell | Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 3 (Homo sapiens (Human)) | BDBM50177565 (CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell | Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50177565 (CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC1R expressed in HEK293 cell | Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6 | |||||||||||
More data for this Ligand-Target Pair |