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BDBM50177602 2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)-2-methylpropan-1-ol::CHEMBL204552

SMILES: CC(C)(CO)Nc1nc(SCc2cccc(Oc3ccccc3)c2)nc2nc(N)sc12

InChI Key: InChIKey=QWRGGCMIFUMWCL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50177602
PNG
(2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]p...)
Show SMILES CC(C)(CO)Nc1nc(SCc2cccc(Oc3ccccc3)c2)nc2nc(N)sc12
Show InChI InChI=1S/C22H23N5O2S2/c1-22(2,13-28)27-19-17-18(24-20(23)31-17)25-21(26-19)30-12-14-7-6-10-16(11-14)29-15-8-4-3-5-9-15/h3-11,28H,12-13H2,1-2H3,(H3,23,24,25,26,27)
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n/an/a 50n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA


Bioorg Med Chem Lett 16: 960-3 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.091
More data for this
Ligand-Target Pair