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BDBM50177604 5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ol::CHEMBL370387

SMILES: Nc1nc2nc(SCc3cccc(F)c3F)[nH]c(=O)c2s1

InChI Key: InChIKey=SFLIILJRMUOVNE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177604   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50177604
PNG
(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]p...)
Show SMILES Nc1nc2nc(SCc3cccc(F)c3F)[nH]c(=O)c2s1
Show InChI InChI=1S/C12H8F2N4OS2/c13-6-3-1-2-5(7(6)14)4-20-12-17-9-8(10(19)18-12)21-11(15)16-9/h1-3H,4H2,(H3,15,16,17,18,19)
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Article
PubMed
n/an/a 270n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA


Bioorg Med Chem Lett 16: 960-3 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.091
BindingDB Entry DOI: 10.7270/Q2D79B09
More data for this
Ligand-Target Pair