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BDBM50177605 (S)-2-(2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-ol::CHEMBL383235

SMILES: CC[C@@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12

InChI Key: InChIKey=NPKHWEBWIFDKHH-NSHDSACASA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177605   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50177605
PNG
((S)-2-(2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimi...)
Show SMILES CC[C@@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12
Show InChI InChI=1S/C16H19N5OS2/c1-2-11(8-22)18-13-12-14(19-15(17)24-12)21-16(20-13)23-9-10-6-4-3-5-7-10/h3-7,11,22H,2,8-9H2,1H3,(H3,17,18,19,20,21)/t11-/m0/s1
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Similars

Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA


Bioorg Med Chem Lett 16: 960-3 (2006)

More data for this
Ligand-Target Pair