BDBM50177835 2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino}-5-(prop-2-yn-1-yloxy)benzo-1,4-quinone::CHEMBL198744

SMILES: COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1

InChI Key: InChIKey=UPQQZTMIRXWKNI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50177835 (2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...) Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:15| Show InChI InChI=1S/C25H26N4O5/c1-3-10-33-22-15-20(30)19(13-21(22)31)28-25-17-12-23(32-2)24(14-18(17)26-16-27-25)34-11-6-9-29-7-4-5-8-29/h1,12,14-16H,4-11,13H2,2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP				J Med Chem 48: 7560-81 (2005) Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50177835 (2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...) Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:15| Show InChI InChI=1S/C25H26N4O5/c1-3-10-33-22-15-20(30)19(13-21(22)31)28-25-17-12-23(32-2)24(14-18(17)26-16-27-25)34-11-6-9-29-7-4-5-8-29/h1,12,14-16H,4-11,13H2,2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione				J Med Chem 48: 7560-81 (2005) Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50177835 (2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...) Show SMILES COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:15| Show InChI InChI=1S/C25H26N4O5/c1-3-10-33-22-15-20(30)19(13-21(22)31)28-25-17-12-23(32-2)24(14-18(17)26-16-27-25)34-11-6-9-29-7-4-5-8-29/h1,12,14-16H,4-11,13H2,2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma				J Med Chem 48: 7560-81 (2005) Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S
					More data for this Ligand-Target Pair