Found 3 hits for monomerid = 50177858 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50177858
(CHEMBL3814859)Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1nc2ccccc2n1-c1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C29H29N9O/c1-3-26(39)33-20-8-10-22(11-9-20)38-25-7-5-4-6-23(25)35-29(38)27-28(30)31-17-24(34-27)19-16-32-37(18-19)21-12-14-36(2)15-13-21/h3-11,16-18,21H,1,12-15H2,2H3,(H2,30,31)(H,33,39) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 3.38E+3 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibitory activity towards acetylcholine esterase (AChE) |
ACS Med Chem Lett 7: 514-9 (2016)
BindingDB Entry DOI: 10.7270/Q2474CSN |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2/Receptor tyrosine-protein kinase erbB-3/Receptor tyrosine-protein kinase erbB-4
(Homo sapiens (Human)) | BDBM50177858
(CHEMBL3814859)Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1nc2ccccc2n1-c1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C29H29N9O/c1-3-26(39)33-20-8-10-22(11-9-20)38-25-7-5-4-6-23(25)35-29(38)27-28(30)31-17-24(34-27)19-16-32-37(18-19)21-12-14-36(2)15-13-21/h3-11,16-18,21H,1,12-15H2,2H3,(H2,30,31)(H,33,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/L858R double mutant autophosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISA |
ACS Med Chem Lett 7: 514-9 (2016)
BindingDB Entry DOI: 10.7270/Q2474CSN |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2/Receptor tyrosine-protein kinase erbB-3/Receptor tyrosine-protein kinase erbB-4
(Homo sapiens (Human)) | BDBM50177858
(CHEMBL3814859)Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1nc2ccccc2n1-c1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C29H29N9O/c1-3-26(39)33-20-8-10-22(11-9-20)38-25-7-5-4-6-23(25)35-29(38)27-28(30)31-17-24(34-27)19-16-32-37(18-19)21-12-14-36(2)15-13-21/h3-11,16-18,21H,1,12-15H2,2H3,(H2,30,31)(H,33,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of EGFR exon19 deletion activating mutant autophosphorylation in human PC9 cells incubated for 2 hrs by ELISA |
ACS Med Chem Lett 7: 514-9 (2016)
BindingDB Entry DOI: 10.7270/Q2474CSN |
More data for this Ligand-Target Pair | |