Found 3 hits for monomerid = 50177862 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50177862
(CHEMBL3814572)Show SMILES CN(C(=O)C=C)c1cccc(c1)-n1c(nc2ccccc12)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1 Show InChI InChI=1S/C30H31N9O/c1-4-27(40)37(3)22-8-7-9-23(16-22)39-26-11-6-5-10-24(26)35-30(39)28-29(31)32-18-25(34-28)20-17-33-38(19-20)21-12-14-36(2)15-13-21/h4-11,16-19,21H,1,12-15H2,2-3H3,(H2,31,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild-type EGFR autophosphorylation in human LoVo cells incubated for 2 hrs followed by EGF-stiumlation for 10 mins by ELISA |
ACS Med Chem Lett 7: 514-9 (2016)
BindingDB Entry DOI: 10.7270/Q2474CSN |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2/Receptor tyrosine-protein kinase erbB-3/Receptor tyrosine-protein kinase erbB-4
(Homo sapiens (Human)) | BDBM50177862
(CHEMBL3814572)Show SMILES CN(C(=O)C=C)c1cccc(c1)-n1c(nc2ccccc12)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1 Show InChI InChI=1S/C30H31N9O/c1-4-27(40)37(3)22-8-7-9-23(16-22)39-26-11-6-5-10-24(26)35-30(39)28-29(31)32-18-25(34-28)20-17-33-38(19-20)21-12-14-36(2)15-13-21/h4-11,16-19,21H,1,12-15H2,2-3H3,(H2,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 390 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of EGFR T790M/L858R double mutant autophosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISA |
ACS Med Chem Lett 7: 514-9 (2016)
BindingDB Entry DOI: 10.7270/Q2474CSN |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2/Receptor tyrosine-protein kinase erbB-3/Receptor tyrosine-protein kinase erbB-4
(Homo sapiens (Human)) | BDBM50177862
(CHEMBL3814572)Show SMILES CN(C(=O)C=C)c1cccc(c1)-n1c(nc2ccccc12)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1 Show InChI InChI=1S/C30H31N9O/c1-4-27(40)37(3)22-8-7-9-23(16-22)39-26-11-6-5-10-24(26)35-30(39)28-29(31)32-18-25(34-28)20-17-33-38(19-20)21-12-14-36(2)15-13-21/h4-11,16-19,21H,1,12-15H2,2-3H3,(H2,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of EGFR exon19 deletion activating mutant autophosphorylation in human PC9 cells incubated for 2 hrs by ELISA |
ACS Med Chem Lett 7: 514-9 (2016)
BindingDB Entry DOI: 10.7270/Q2474CSN |
More data for this Ligand-Target Pair | |