BDBM50178910 9-cyclopropyl-6-fluoro-7-(5-(piperidin-2-yl)pyridin-3-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione::CHEMBL380533

SMILES: Fc1cc2c(cc1-c1cncc(c1)C1CCCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O

InChI Key: InChIKey=JWMUMIGYFFWLMX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50178910   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178910 (9-cyclopropyl-6-fluoro-7-(5-(piperidin-2-yl)pyridi...) Show SMILES Fc1cc2c(cc1-c1cncc(c1)C1CCCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C23H21FN4O2S/c24-17-8-16-19(28(14-4-5-14)23-20(21(16)29)22(30)27-31-23)9-15(17)12-7-13(11-25-10-12)18-3-1-2-6-26-18/h7-11,14,18,26H,1-6H2,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair