BDBM50179337 (4,5-difluoro-1H-benzoimidazol-2-yl)(4-methylpiperazin-1-yl)methanone::CHEMBL338972
SMILES: CN1CCN(CC1)C(=O)c1nc2ccc(F)c(F)c2[nH]1
InChI Key: InChIKey=SOTVKFXJVXTVDW-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50179337 ((4,5-difluoro-1H-benzoimidazol-2-yl)(4-methylpiper...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells | J Med Chem 48: 8289-98 (2005) Article DOI: 10.1021/jm0502081 BindingDB Entry DOI: 10.7270/Q2C24W00 | |||||||||||
More data for this Ligand-Target Pair |