new BindingDB logo
myBDB logout

BDBM50179742 (3S)-3-((S)-4-methyl-2-((S)-4-methyl-2-(10H-phenothiazine-2-carboxamido)pentanamido)pentanamido)-tetrahydrofuran-2-yl acetate::CHEMBL206571

SMILES: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1OC(C)=O

InChI Key: InChIKey=BNGWXRGSXSJXMS-ZVUCNBDQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50179742   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calpain 1/small subunit 1


(Homo sapiens (Human))
BDBM50179742
PNG
((3S)-3-((S)-4-methyl-2-((S)-4-methyl-2-(10H-phenot...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1ccc2Sc3ccccc3Nc2c1)C(=O)N[C@H]1CCOC1OC(C)=O
Show InChI InChI=1S/C31H40N4O6S/c1-17(2)14-24(34-28(37)20-10-11-27-23(16-20)32-21-8-6-7-9-26(21)42-27)30(39)35-25(15-18(3)4)29(38)33-22-12-13-40-31(22)41-19(5)36/h6-11,16-18,22,24-25,31-32H,12-15H2,1-5H3,(H,33,38)(H,34,37)(H,35,39)/t22-,24-,25-,31?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 905n/an/an/an/an/an/a



Institut Henri Beaufour

Curated by ChEMBL


Assay Description
Inhibition of isolated human calpain1


Bioorg Med Chem Lett 16: 1586-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.036
BindingDB Entry DOI: 10.7270/Q2T15367
More data for this
Ligand-Target Pair