BDBM50180273 CHEMBL3815042

SMILES: COc1cn(CC(F)(F)F)nc(-c2ccnn2-c2ccccc2)c1=O

InChI Key: InChIKey=UGVZZMAOENVVLZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50180273   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50180273 (CHEMBL3815042) Show SMILES COc1cn(CC(F)(F)F)nc(-c2ccnn2-c2ccccc2)c1=O Show InChI InChI=1S/C16H13F3N4O2/c1-25-13-9-22(10-16(17,18)19)21-14(15(13)24)12-7-8-20-23(12)11-5-3-2-4-6-11/h2-9H,10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human full length PDE10A2 expressed in African green monkey COS7 cells using [3H]cGMP as substrate preincubated for 30 mins followed by...				Bioorg Med Chem 24: 3447-55 (2016) BindingDB Entry DOI: 10.7270/Q2H9974G
					More data for this Ligand-Target Pair