BDBM50180708 7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one::CHEMBL199393

SMILES: CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1

InChI Key: InChIKey=ZJASONAERXCSAC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50180708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50180708 (7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...) Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of low pH activation of human TRPV1				J Med Chem 49: 471-4 (2006) Article DOI: 10.1021/jm051058x BindingDB Entry DOI: 10.7270/Q2RX9BNT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50180708 (7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...) Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of low pH activation of rat TRPV1				J Med Chem 49: 471-4 (2006) Article DOI: 10.1021/jm051058x BindingDB Entry DOI: 10.7270/Q2RX9BNT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50180708 (7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...) Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of calcium influx evoked by capsaicin in rat TRPV1 expressing cells by fluorescence assay				J Med Chem 49: 471-4 (2006) Article DOI: 10.1021/jm051058x BindingDB Entry DOI: 10.7270/Q2RX9BNT
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50180708 (7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...) Show SMILES CC(C)(C)c1nc2[nH]c(=S)[nH]c(=O)c2cc1-c1ccccc1 Show InChI InChI=1S/C17H17N3OS/c1-17(2,3)13-11(10-7-5-4-6-8-10)9-12-14(18-13)19-16(22)20-15(12)21/h4-9H,1-3H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assay				J Med Chem 49: 471-4 (2006) Article DOI: 10.1021/jm051058x BindingDB Entry DOI: 10.7270/Q2RX9BNT
					More data for this Ligand-Target Pair