BDBM50181298 5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylic acid::CHEMBL378376
SMILES: O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)C(F)(F)F
InChI Key: InChIKey=JYZXGURJKNAFPT-ZWKOTPCHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostanoid EP4 receptor (Rattus norvegicus) | BDBM50181298 (5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation | Bioorg Med Chem Lett 16: 1799-802 (2006) Article DOI: 10.1016/j.bmcl.2006.01.018 BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid EP2 receptor (Rattus norvegicus) | BDBM50181298 (5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 483 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Binding affinity to rat EP2 receptor expressed in HEK293 cells | Bioorg Med Chem Lett 16: 1799-802 (2006) Article DOI: 10.1016/j.bmcl.2006.01.018 BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid EP2 receptor (Rattus norvegicus) | BDBM50181298 (5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 483 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Binding affinity to rat EP2 receptor | J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid EP4 receptor (Rattus norvegicus) | BDBM50181298 (5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activation | J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid EP4 receptor (Rattus norvegicus) | BDBM50181298 (5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Binding affinity to rat EP4 receptor | J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid EP4 receptor (Rattus norvegicus) | BDBM50181298 (5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Binding affinity to rat EP4 receptor expressed in HEK293 cells | Bioorg Med Chem Lett 16: 1799-802 (2006) Article DOI: 10.1016/j.bmcl.2006.01.018 BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 | |||||||||||
More data for this Ligand-Target Pair |