BindingDB PrimarySearch

BDBM50181311 4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydroquinolin-2-one::4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one::CHEMBL204426

SMILES: Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12

InChI Key: InChIKey=JZGWDENJLOXKLZ-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50181311
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Chiron Corporation Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta				Bioorg Med Chem Lett 16: 2247-51 (2006) Article DOI: 10.1016/j.bmcl.2006.01.020 BindingDB Entry DOI: 10.7270/Q2NZ8777
Chiron Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Mus musculus)	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Chiron Corporation Curated by ChEMBL					Assay Description Inhibitory activity against VEGFR2				Bioorg Med Chem Lett 16: 2247-51 (2006) Article DOI: 10.1016/j.bmcl.2006.01.020 BindingDB Entry DOI: 10.7270/Q2NZ8777
Chiron Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Chiron Corporation Curated by ChEMBL					Assay Description Inhibitory activity against FGFR1				Bioorg Med Chem Lett 16: 2247-51 (2006) Article DOI: 10.1016/j.bmcl.2006.01.020 BindingDB Entry DOI: 10.7270/Q2NZ8777
Chiron Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant FGFR1				J Med Chem 52: 278-92 (2009) Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant PDGFRbeta				J Med Chem 52: 278-92 (2009) Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR2				J Med Chem 52: 278-92 (2009) Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50181311 (4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chiron Corporation Curated by ChEMBL					Assay Description Inhibitory activity against VEGFR1				Bioorg Med Chem Lett 16: 2247-51 (2006) Article DOI: 10.1016/j.bmcl.2006.01.020 BindingDB Entry DOI: 10.7270/Q2NZ8777
Chiron Corporation Curated by ChEMBL					More data for this Ligand-Target Pair