BDBM50181556 6-methoxy-N-(5-methyl-1,3-thiazol-2-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine::CHEMBL201654

SMILES: COc1cc2c(Nc3ncc(C)s3)ncnc2cc1OCCCN1CCOCC1

InChI Key: InChIKey=ANIODNBRYFSVJO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50181556   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50181556 (6-methoxy-N-(5-methyl-1,3-thiazol-2-yl)-7-(3-morph...) Show SMILES COc1cc2c(Nc3ncc(C)s3)ncnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C20H25N5O3S/c1-14-12-21-20(29-14)24-19-15-10-17(26-2)18(11-16(15)22-13-23-19)28-7-3-4-25-5-8-27-9-6-25/h10-13H,3-9H2,1-2H3,(H,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description In vitro inhibition constant for Aurora-A				J Med Chem 49: 955-70 (2006) Article DOI: 10.1021/jm050786h BindingDB Entry DOI: 10.7270/Q24J0FXV
					More data for this Ligand-Target Pair