BDBM50182173 4-[7-chloro-1-(2,6-difluoro-benzyl)-1H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophene-2-carboxamidine::CHEMBL382443

SMILES: CSc1sc(cc1S(=O)(=O)c1cc(Cl)c2n(Cc3c(F)cccc3F)cnc2c1)C(N)=N

InChI Key: InChIKey=HSWLNDVLTBAZKG-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50182173   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement C1s subcomponent (Homo sapiens (Human))	BDBM50182173 (4-[7-chloro-1-(2,6-difluoro-benzyl)-1H-benzoimidaz...) Show SMILES CSc1sc(cc1S(=O)(=O)c1cc(Cl)c2n(Cc3c(F)cccc3F)cnc2c1)C(N)=N Show InChI InChI=1S/C20H15ClF2N4O2S3/c1-30-20-17(7-16(31-20)19(24)25)32(28,29)10-5-12(21)18-15(6-10)26-9-27(18)8-11-13(22)3-2-4-14(11)23/h2-7,9H,8H2,1H3,(H3,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of C1S				Bioorg Med Chem Lett 16: 2200-4 (2006) Article DOI: 10.1016/j.bmcl.2006.01.036 BindingDB Entry DOI: 10.7270/Q2251HSV
					More data for this Ligand-Target Pair