BDBM50182294 CHEMBL3817984
SMILES: CCn1c2nc(NC3COC3)ncc2cc(-c2ccc(cc2Cl)-n2cccc(C)c2=O)c1=O
InChI Key: InChIKey=YJZIVGDUWQTSQX-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM50182294 (CHEMBL3817984) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Chempartner Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as ... | J Med Chem 59: 5520-41 (2016) BindingDB Entry DOI: 10.7270/Q23X88KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 2 (Homo sapiens (Human)) | BDBM50182294 (CHEMBL3817984) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Chempartner Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol... | J Med Chem 59: 5520-41 (2016) BindingDB Entry DOI: 10.7270/Q23X88KT | |||||||||||
More data for this Ligand-Target Pair |