BDBM50182362 4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine::4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine::4-[7-dimethylaminomethyl-2-(4-fluorophenyl)imidazo[1,2,-a]pyridin-3-yl]pyrimidin-2-ylamine::CHEMBL425949
SMILES: CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
InChI Key: InChIKey=HEPQZLAAWOEYMZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-dependent protein kinase (Eimeria tenella) | BDBM50182362 (4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...) | UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against PKG | Bioorg Med Chem Lett 16: 2479-83 (2006) Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-dependent protein kinase (Eimeria tenella) | BDBM50182362 (4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...) | UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
SCYNEXIS, Inc. Curated by ChEMBL | Assay Description Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay | Eur J Med Chem 42: 1334-57 (2007) Article DOI: 10.1016/j.ejmech.2007.02.006 BindingDB Entry DOI: 10.7270/Q2SB45FM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-dependent protein kinase 1 beta (Homo sapiens (Human)) | BDBM50182362 (4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
LifeArc Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His6-tagged full length PKG1beta expressed in baculovirus infected Sf21 insect cells | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.08.014 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CGMP-dependent protein kinase (Plasmodium falciparum) | BDBM50182362 (4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
LifeArc Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum protein kinase G | Bioorg Med Chem Lett 28: 3168-3173 (2018) Article DOI: 10.1016/j.bmcl.2018.08.028 BindingDB Entry DOI: 10.7270/Q21Z473B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-dependent protein kinase 1 beta (Homo sapiens (Human)) | BDBM50182362 (4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
LifeArc Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His6-tagged full length PKG1alpha expressed in baculovirus infected Sf21 insect cells | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.08.014 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-dependent protein kinase (Eimeria tenella) | BDBM50182362 (4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...) | UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
SCYNEXIS, Inc. Curated by ChEMBL | Assay Description Inhibition of Eimeria tenella cGMP-dependent protein kinase | Eur J Med Chem 43: 1123-51 (2008) Article DOI: 10.1016/j.ejmech.2007.09.013 BindingDB Entry DOI: 10.7270/Q28C9W1H | |||||||||||
More data for this Ligand-Target Pair |