BDBM50182492 CHEMBL3818387::US9512121, 16

SMILES: CN1C(=O)COc2c1cnc1ccc(Sc3nnc4ccc(cn34)-c3cnn(C)c3)cc21

InChI Key: InChIKey=CGXIXBIPOPIDFO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50182492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50182492 (CHEMBL3818387 | US9512121, 16) Show SMILES CN1C(=O)COc2c1cnc1ccc(Sc3nnc4ccc(cn34)-c3cnn(C)c3)cc21 Show InChI InChI=1S/C22H17N7O2S/c1-27-10-14(8-24-27)13-3-6-19-25-26-22(29(19)11-13)32-15-4-5-17-16(7-15)21-18(9-23-17)28(2)20(30)12-31-21/h3-11H,12H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis				Bioorg Med Chem 24: 3483-93 (2016) BindingDB Entry DOI: 10.7270/Q29G5PQT
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50182492 (CHEMBL3818387 | US9512121, 16) Show SMILES CN1C(=O)COc2c1cnc1ccc(Sc3nnc4ccc(cn34)-c3cnn(C)c3)cc21 Show InChI InChI=1S/C22H17N7O2S/c1-27-10-14(8-24-27)13-3-6-19-25-26-22(29(19)11-13)32-15-4-5-17-16(7-15)21-18(9-23-17)28(2)20(30)12-31-21/h3-11H,12H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	20
Jiangsu Hansoh Pharmaceutical Co., Ltd. US Patent					Assay Description Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...				US Patent US9512121 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NSV
					More data for this Ligand-Target Pair