BDBM50182495 CHEMBL3818361::US9512121, 20
SMILES: COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4ccc(cn34)-c3cnn(C)c3)cc21
InChI Key: InChIKey=AMTZWSOKTLFGIU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50182495 (CHEMBL3818361 | US9512121, 20) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Southeast University Curated by ChEMBL | Assay Description Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis | Bioorg Med Chem 24: 3483-93 (2016) BindingDB Entry DOI: 10.7270/Q29G5PQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50182495 (CHEMBL3818361 | US9512121, 20) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 20.1 | n/a | n/a | n/a | n/a | n/a | 20 |
Jiangsu Hansoh Pharmaceutical Co., Ltd. US Patent | Assay Description Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ... | US Patent US9512121 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NSV | |||||||||||
More data for this Ligand-Target Pair |