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BDBM50182517 CHEMBL3818928::US9512121, 21

SMILES: COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21

InChI Key: InChIKey=MQPZDWFLEKAFOY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50182517   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50182517
PNG
(CHEMBL3818928 | US9512121, 21)
Show SMILES COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21
Show InChI InChI=1S/C24H20FN7O3S/c1-30-11-15(9-27-30)14-7-18(25)23-28-29-24(32(23)12-14)36-16-3-4-19-17(8-16)22-20(10-26-19)31(5-6-34-2)21(33)13-35-22/h3-4,7-12H,5-6,13H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 11n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis


Bioorg Med Chem 24: 3483-93 (2016)


BindingDB Entry DOI: 10.7270/Q29G5PQT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50182517
PNG
(CHEMBL3818928 | US9512121, 21)
Show SMILES COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21
Show InChI InChI=1S/C24H20FN7O3S/c1-30-11-15(9-27-30)14-7-18(25)23-28-29-24(32(23)12-14)36-16-3-4-19-17(8-16)22-20(10-26-19)31(5-6-34-2)21(33)13-35-22/h3-4,7-12H,5-6,13H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 11.4n/an/an/an/an/a20



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...


US Patent US9512121 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NSV
More data for this
Ligand-Target Pair