BDBM50182517 CHEMBL3818928::US9512121, 21

SMILES: COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21

InChI Key: InChIKey=MQPZDWFLEKAFOY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50182517   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50182517 (CHEMBL3818928 | US9512121, 21) Show SMILES COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21 Show InChI InChI=1S/C24H20FN7O3S/c1-30-11-15(9-27-30)14-7-18(25)23-28-29-24(32(23)12-14)36-16-3-4-19-17(8-16)22-20(10-26-19)31(5-6-34-2)21(33)13-35-22/h3-4,7-12H,5-6,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis				Bioorg Med Chem 24: 3483-93 (2016) BindingDB Entry DOI: 10.7270/Q29G5PQT
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50182517 (CHEMBL3818928 | US9512121, 21) Show SMILES COCCN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21 Show InChI InChI=1S/C24H20FN7O3S/c1-30-11-15(9-27-30)14-7-18(25)23-28-29-24(32(23)12-14)36-16-3-4-19-17(8-16)22-20(10-26-19)31(5-6-34-2)21(33)13-35-22/h3-4,7-12H,5-6,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	20
Jiangsu Hansoh Pharmaceutical Co., Ltd. US Patent					Assay Description Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...				US Patent US9512121 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NSV
					More data for this Ligand-Target Pair