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BDBM50182667 3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-difluoro-7-quinolyl)-4-(3-hydroxymethylpiperazinyl)]butyl}-6-(3-ethyl-4-methylanilino)uracil::CHEMBL202534

SMILES: CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3CO)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C

InChI Key: InChIKey=XHSSTBPTQHSWCP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50182667   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA polymerase IIIC


(Bacillus subtilis)		BDBM50182667
PNG
(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-difluor...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3CO)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C35H40F2N6O6/c1-3-21-14-22(7-6-20(21)2)38-28-16-29(45)42(35(49)39-28)11-5-4-10-40-12-13-41(17-24(40)19-44)32-27(36)15-25-31(30(32)37)43(23-8-9-23)18-26(33(25)46)34(47)48/h6-7,14-16,18,23-24,38,44H,3-5,8-13,17,19H2,1-2H3,(H,39,49)(H,47,48)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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Article
PubMed
 11n/an/an/an/an/an/an/an/a



GLSynthesis Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Bacillus subtilis DNA polymerase3C

J Med Chem 49: 1455-65 (2006)


Article DOI: 10.1021/jm0510023
BindingDB Entry DOI: 10.7270/Q23J3DR1
More data for this
Ligand-Target Pair