BDBM50182944 4-((S)-2-amino-3-oxo-3-((S)-2-(4-phenyl-1H-imidazol-2-yl)piperidin-1-yl)propyl)benzamide::CHEMBL204996
SMILES: N[C@@H](Cc1ccc(cc1)C(N)=O)C(=O)N1CCCC[C@H]1c1nc(c[nH]1)-c1ccccc1
InChI Key: InChIKey=YALMCURVZITNRZ-FPOVZHCZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50182944 (4-((S)-2-amino-3-oxo-3-((S)-2-(4-phenyl-1H-imidazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from mu opioid receptor in rat brain | Bioorg Med Chem Lett 16: 2505-8 (2006) Article DOI: 10.1016/j.bmcl.2006.01.082 BindingDB Entry DOI: 10.7270/Q29G5MDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50182944 (4-((S)-2-amino-3-oxo-3-((S)-2-(4-phenyl-1H-imidazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]DPDPE from delta opioid receptor in rat brain | Bioorg Med Chem Lett 16: 2505-8 (2006) Article DOI: 10.1016/j.bmcl.2006.01.082 BindingDB Entry DOI: 10.7270/Q29G5MDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50182944 (4-((S)-2-amino-3-oxo-3-((S)-2-(4-phenyl-1H-imidazo...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Activity against mu opioid receptor by stimulation of [35S]GTPgammaS binding in CHO-hgamma cells | Bioorg Med Chem Lett 16: 2505-8 (2006) Article DOI: 10.1016/j.bmcl.2006.01.082 BindingDB Entry DOI: 10.7270/Q29G5MDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (MOUSE) | BDBM50182944 (4-((S)-2-amino-3-oxo-3-((S)-2-(4-phenyl-1H-imidazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 730 | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Activity against delta opioid receptor by stimulation of [35S]GTPgammaS binding in CHO-hgamma cells | Bioorg Med Chem Lett 16: 2505-8 (2006) Article DOI: 10.1016/j.bmcl.2006.01.082 BindingDB Entry DOI: 10.7270/Q29G5MDZ | |||||||||||
More data for this Ligand-Target Pair |