BDBM50183201 CHEMBL379722::N-(2-chloro-4-sulfamoyl-phenyl)-2-[1-(2,4,6-trimethyl-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide
SMILES: Cc1cc(C)c(c(C)c1)-n1nnnc1SCC(=O)Nc1ccc(cc1Cl)S(N)(=O)=O
InChI Key: InChIKey=UBXXFDJETHMQAG-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50183201 (CHEMBL379722 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
MRL Rome Curated by ChEMBL | Assay Description Inhibition of HIV1 wild type Reverse Transcriptase | Bioorg Med Chem Lett 16: 2748-52 (2006) Article DOI: 10.1016/j.bmcl.2006.02.024 BindingDB Entry DOI: 10.7270/Q2D79B1R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50183201 (CHEMBL379722 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assay | Bioorg Med Chem Lett 18: 2959-66 (2008) Article DOI: 10.1016/j.bmcl.2008.03.064 BindingDB Entry DOI: 10.7270/Q2HT2S4M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50183201 (CHEMBL379722 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase Y181C mutant by SPA assay | Bioorg Med Chem Lett 18: 2959-66 (2008) Article DOI: 10.1016/j.bmcl.2008.03.064 BindingDB Entry DOI: 10.7270/Q2HT2S4M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50183201 (CHEMBL379722 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase by SPA assay | Bioorg Med Chem Lett 18: 2959-66 (2008) Article DOI: 10.1016/j.bmcl.2008.03.064 BindingDB Entry DOI: 10.7270/Q2HT2S4M | |||||||||||
More data for this Ligand-Target Pair |