Found 5 hits for monomerid = 50183788 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50183788
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C25H23N3O3S/c1-25(2,32(3,30)31)20-15-18-8-5-11-27-23(18)22(16-20)17-6-4-7-19(14-17)24(29)28-21-9-12-26-13-10-21/h4-16H,1-3H3,(H,26,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4B |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50183788
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C25H23N3O3S/c1-25(2,32(3,30)31)20-15-18-8-5-11-27-23(18)22(16-20)17-6-4-7-19(14-17)24(29)28-21-9-12-26-13-10-21/h4-16H,1-3H3,(H,26,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4D |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50183788
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C25H23N3O3S/c1-25(2,32(3,30)31)20-15-18-8-5-11-27-23(18)22(16-20)17-6-4-7-19(14-17)24(29)28-21-9-12-26-13-10-21/h4-16H,1-3H3,(H,26,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole blood |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Homo sapiens (Human)) | BDBM50183788
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C25H23N3O3S/c1-25(2,32(3,30)31)20-15-18-8-5-11-27-23(18)22(16-20)17-6-4-7-19(14-17)24(29)28-21-9-12-26-13-10-21/h4-16H,1-3H3,(H,26,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4C |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50183788
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O Show InChI InChI=1S/C25H23N3O3S/c1-25(2,32(3,30)31)20-15-18-8-5-11-27-23(18)22(16-20)17-6-4-7-19(14-17)24(29)28-21-9-12-26-13-10-21/h4-16H,1-3H3,(H,26,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4A |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |