BDBM50183793 CHEMBL206592::N-(4-(methylsulfonyl)phenyl)-N-(1-(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)phenyl)ethyl)nicotinamide

SMILES: CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O

InChI Key: InChIKey=QIESARUEQVCDIR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50183793 (CHEMBL206592 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...) Show SMILES CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O Show InChI InChI=1S/C34H33N3O5S2/c1-23(37(33(38)27-12-7-17-35-22-27)29-13-15-30(16-14-29)43(4,39)40)24-9-6-10-25(19-24)31-21-28(34(2,3)44(5,41)42)20-26-11-8-18-36-32(26)31/h6-23H,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human GST-PDE4C				Bioorg Med Chem Lett 16: 2608-12 (2006) Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50183793 (CHEMBL206592 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...) Show SMILES CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O Show InChI InChI=1S/C34H33N3O5S2/c1-23(37(33(38)27-12-7-17-35-22-27)29-13-15-30(16-14-29)43(4,39)40)24-9-6-10-25(19-24)31-21-28(34(2,3)44(5,41)42)20-26-11-8-18-36-32(26)31/h6-23H,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human GST-PDE4D				Bioorg Med Chem Lett 16: 2608-12 (2006) Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50183793 (CHEMBL206592 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...) Show SMILES CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O Show InChI InChI=1S/C34H33N3O5S2/c1-23(37(33(38)27-12-7-17-35-22-27)29-13-15-30(16-14-29)43(4,39)40)24-9-6-10-25(19-24)31-21-28(34(2,3)44(5,41)42)20-26-11-8-18-36-32(26)31/h6-23H,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole blood				Bioorg Med Chem Lett 16: 2608-12 (2006) Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50183793 (CHEMBL206592 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...) Show SMILES CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O Show InChI InChI=1S/C34H33N3O5S2/c1-23(37(33(38)27-12-7-17-35-22-27)29-13-15-30(16-14-29)43(4,39)40)24-9-6-10-25(19-24)31-21-28(34(2,3)44(5,41)42)20-26-11-8-18-36-32(26)31/h6-23H,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human GST-PDE4B				Bioorg Med Chem Lett 16: 2608-12 (2006) Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50183793 (CHEMBL206592 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...) Show SMILES CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O Show InChI InChI=1S/C34H33N3O5S2/c1-23(37(33(38)27-12-7-17-35-22-27)29-13-15-30(16-14-29)43(4,39)40)24-9-6-10-25(19-24)31-21-28(34(2,3)44(5,41)42)20-26-11-8-18-36-32(26)31/h6-23H,1-5H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human GST-PDE4A				Bioorg Med Chem Lett 16: 2608-12 (2006) Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N
					More data for this Ligand-Target Pair