Found 5 hits for monomerid = 50183800 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50183800
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-(1-(3-(...)Show SMILES CC(C)NC(=O)N(C(C)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C32H37N3O5S2/c1-21(2)34-31(36)35(27-13-15-28(16-14-27)41(6,37)38)22(3)23-10-8-11-24(18-23)29-20-26(32(4,5)42(7,39)40)19-25-12-9-17-33-30(25)29/h8-22H,1-7H3,(H,34,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4A |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50183800
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-(1-(3-(...)Show SMILES CC(C)NC(=O)N(C(C)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C32H37N3O5S2/c1-21(2)34-31(36)35(27-13-15-28(16-14-27)41(6,37)38)22(3)23-10-8-11-24(18-23)29-20-26(32(4,5)42(7,39)40)19-25-12-9-17-33-30(25)29/h8-22H,1-7H3,(H,34,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole blood |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50183800
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-(1-(3-(...)Show SMILES CC(C)NC(=O)N(C(C)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C32H37N3O5S2/c1-21(2)34-31(36)35(27-13-15-28(16-14-27)41(6,37)38)22(3)23-10-8-11-24(18-23)29-20-26(32(4,5)42(7,39)40)19-25-12-9-17-33-30(25)29/h8-22H,1-7H3,(H,34,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4B |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50183800
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-(1-(3-(...)Show SMILES CC(C)NC(=O)N(C(C)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C32H37N3O5S2/c1-21(2)34-31(36)35(27-13-15-28(16-14-27)41(6,37)38)22(3)23-10-8-11-24(18-23)29-20-26(32(4,5)42(7,39)40)19-25-12-9-17-33-30(25)29/h8-22H,1-7H3,(H,34,36) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4D |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Homo sapiens (Human)) | BDBM50183800
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-(1-(3-(...)Show SMILES CC(C)NC(=O)N(C(C)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C32H37N3O5S2/c1-21(2)34-31(36)35(27-13-15-28(16-14-27)41(6,37)38)22(3)23-10-8-11-24(18-23)29-20-26(32(4,5)42(7,39)40)19-25-12-9-17-33-30(25)29/h8-22H,1-7H3,(H,34,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human GST-PDE4C |
Bioorg Med Chem Lett 16: 2608-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.043 BindingDB Entry DOI: 10.7270/Q2F18Z9N |
More data for this Ligand-Target Pair | |